By: Mahdieh Danesh Yazdi – We live in amazing times. Technology does not progress by steps anymore, it grows by leaps. Health-care has reaped the benefits of these advances just like any other industry. It was not a very long time ago that pharmacists would look up patient records in a book full of names…

By: Elsa Thomas, Pharm.D. c/o 2013 – Human body uses various complex mechanisms to maintain its body temperature within a narrow range despite extreme environmental temperature changes as well as physiological changes. Several factors can affect body temperature such as disease states, growth, exercise, hormonal changes, and medications. Hypothermia can occurs as a result of…

By: Steve Soman, Pharm.D. Candidate c/o 2013 – Bisphosphonates are proven to enhance bone density and reduce fracture incidence in post-menopausal women but recent data suggests they may have adverse effects with regards to bone quality.  The drugs in this class can be differentiated as non-nitrogen containing (older generation) and nitrogen containing (newer generation) medications.…

By: Marina Yermolayeva, PharmD Candidate c/o 2013 – “I’m allergic to the generic; I need the brand name medication,” is a common claim heard by many health care providers.  Managed care organizations get numerous calls from doctors and patients requesting prior authorizations to approve brand name medications whilst there are generic alternatives available on formulary.…

By: Neal Shah, Co-Editor-In-Chief – Migraines can be “classic” or “common.”  While all migraines feature unilateral, pulsating headaches, classic migraines feature an “aura” upon onset (whereas common migraines do not).  Pharmacologic treatment of migraines generally includes serotonin agonists (triptans).1 Triptans are selective agonists of the 5-hydroxytryptamine 1B and 1D (5HT1B/1D) subtypes.  By activating these receptors,…

By: Mohamed Dungersi, Associate Student Editor –  Match the following herbal products with their correct description: A. This product has been used to treat liver disease, including hepatitis and cirrhosis.  It has also been used as a protective agent after the liver was exposed to alcohol, acetaminophen, and carbon tetrachloride.B. This product is extracted from…

By: Neal Shah, Co-Editor-in-Chief –  Dialysis is the removal of substances from intravascular circulation by filtration.1  Typically, dialysis is ordered when kidney function declines to 10–15% of normal function.2  The National Kidney Foundation’s Kidney Disease Outcome Quality Initiative (K/DOQI) recommends that planning for dialysis begin when patients reach chronic kidney disease stage 4, which is…

By: Steve P. Soman – Mirabegron (Mybetriq®), known also by the brand name Betanis®in Japan, is a new once daily oral drug.   First in its class, it is a selective β(3)-adrenoceptor agonist that improves symptoms associated with over active bladder (OAB) such as urinary incontinence, urgency, and urinary frequency by enhancing storage function and relaxing…

By Mohamed Dungersi, Associate Student Editor – Match the following herbal products with their natural source and reason for use: A. This product is a source of omega-3 fatty acids, primarily docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).  It is used to lower triglyceride levels, to lower high blood pressure, and for a variety of…

By: Lunbao (Jerry) Huang, Pharm.D. Candidate c/o 2013 – Donepezil, brand name Aricept®, is an acetylcholinesterase inhibitor indicated as monotherapy for Alzheimer’s disease, the most common form of dementia.  Cholinergic deficiency in the cortex and basal forebrain contributes to cognitive deficits in these patients.  Donepezil reversibly, noncompetitively inhibits centrally active acetylcholinesterase, the enzyme responsible for…

By: Neal Shah, Co Editor-In-Chief – Dyskinesias are abnormal, involuntary movement disorders.  Subsets of dyskinesias include choreas and atheosis.  Chorea is irregular and sporadic contraction of muscles whereas athetosis involves a twisting and writhing of muscles.  These two dyskinesias often occur together and are thus termed choreathetosis.1  Common conditions which feature choreatheosis are Huntington’s, and…

By: Neal Shah, Co Editor-In-Chief – Pure Red Cell Aplasia (PRCA), also known as erythroblastopenia, is characterized by a suppression of erythrocytes in the bone marrow.  It is a peculiar oddity that the bone marrow’s progenitor cells still differentiate into white blood cells and platelets.1  PRCA has idiopathic, viral, auto-immune, and genetic etiologies.  Diamond-Blackfan syndrome…

By: Shannon Tellier, Associate Student Editor – The disease burden in children outweighs the number of pediatric clinical drug trials currently being conducted.  The lack of data in pediatrics leads to drugs being used off-label and without sufficient knowledge of doses, tolerability, and efficacy.  In 1975, only 22% of products in the electronic Physicians’ Desk…

By: Raymond Wu, Pharm.D. Candidate c/o 2013   The 5-hydroxytryptamine type 3 (5HT3) antagonists (e.g. ondansetron [Zofran®]) are commonly used in the prevention and treatment of nausea and vomiting in the inpatient setting.1  Overall, ondansetron is a well-tolerated medication with few side effects.1  Constipation, dizziness, and headache are the most commonly reported side effects associated…

By: Marie Huang –       Each month, the Rho Chi Post has the wonderful opportunity to sit down with an inspiring leader among the student pharmacists here at St. John’s University College of Pharmacy and Health Sciences – someone who is not afraid to stand apart from the crowd and can be the change he…

By: Mahdieh Danesh Yazdi, Associate Student Editor, with Special Thanks to Dr. Tomasz Jodlowski for his contributions to this article – In the 1990s, major urban and rural areas across the United States grappled with a common problem: drug addiction.  At that time, the drugs of choice were illicit substances (i.e. heroin).  In order to combat…

By: Lauren Kaveski, Pharm.D. Candidate c/o 2013 – We see proton pump inhibitors (PPIs) used in many medication regimens, but it is unknown whether the majority of patients receive these medications for appropriate durations or indications.  For all labeled indications, other than Zollinger-Ellison Syndrome (a rare condition characterized by damaging gastrin hypersecretion and subsequent hydrochloric…

By: Mohamed Dungersi & Mahdieh Danesh Yazdi, Associate Student Editors – Each month, the editors at the Rho Chi Post have the opportunity to interview one or more of our faculty members. This month, we had the tremendous opportunity to interview the dean of St. John’s University College of Pharmacy and Allied Health Professions, Dean…

By: Sylva Ohanian, Pharm.D. Candidate c/o 2017  –             Finally, I understood the hype. Impatience rendered my heart anew as I rushed into an epiphany 1,353 feet above Chicago. The Skydeck was flooded with tourists and natives alike, continuously breaking record-numbers in visitors. Why do they continue to come en masse here? Is it the…

By: Sanjay Dave, Supervising Pharmacist, Class of 1985 St. John’s University College of Pharmacy and Allied Health Professions – Mr. Sanjay Dave is a St. John’s University College of Pharmacy and Allied Health Professions Graduate, Class of 1985.  Since graduation, he has worked for Pathmark Pharmacies and is currently the supervising pharmacist at Pathmark Pharmacy…

By: Mohamed Dungersi, Associate Student Editor – Dr. William Maidhof is an Assistant Professor and Industry Professional in the Clinical Pharmacy Practice department of the St. John’s University College of Pharmacy and Allied Health Professions. He is an alumnus of St. John’s University who graduated in 1999 with a BS in Pharmacy and again in…

By: Lunbao Huang Pharm D. Candidate c/o 2013 – The seventh report of the Joint National Committee on high blood pressure (JNC-7) states that most classes of antihypertensive drugs such as angiotensin converting enzyme inhibitors (ACEIs), angiotensin-II receptor blockers (ARBs), beta-blockers (BBs), diuretics, and aldosterone-receptor antagonists can be used for hypertensive heart failure patients except…

By: Kathlynn Ferrer, Pharm.D. Candidate c/o 2013 – Nabiximols (Sativex®) is a buccal spray that has been approved for use in the UK, Spain, Germany, Denmark, New Zealand, and Canada. The active ingredients in this product are Tetrahydrocannabinol and Cannabidiol, two kinds of cannabinoids1. Cannabinoids are chemical compounds that stimulate cannabinoid receptors and are the…

By: Alexandra Alleva, Pharm.D. Candidate c/o 2013 – On February 17, 2012, the US Food and Drug Administration (FDA) approved the first medication indicated specifically for patients with endogenous Cushing’s syndrome, a hormone disorder characterized by elevated blood levels of cortisol.  Mifepristone (Korlym®) is for the treatment of glucose intolerance and Type 2 Diabetes Mellitus…

By: Mahdieh Danesh Yazdi – In previous issues, we discussed prescription drug abuse and several bills currently on the floor of the NYS Legislature, sponsored by Sen. Hannon which addressed the issue. On February 7th, I sat down with Sen. Hannon’s director of communications, Mr. Phil Hecken, and his legislative aide, Mr. Timothy Broschardt to…

By: Yufan (Frank) Liu, Pharm.D. Candidate c/o 2013 – Results of numerous epidemiological studies have indicated that having high serum cholesterol can lead to coronary heart disease (CHD). 1 More specifically having high LDL cholesterol puts patients at risk for angina and heart attack.2 To reduce this risk HMG-CoA reductase inhibitors, also known as statins,…

By: Shannon Tellier – Medication related problems can be reduced in older adults if the Beers Criteria were utilized by health care professionals. The criteria serves as a guideline to identify potentially inappropriate medications (PIMs) that should be avoided in the elderly population, but it should not replace clinical judgment. This 2012 update includes a…

By: Lunbao (Jerry) Huang, Pharm.D. Candidate c/o 2013 – Counterfeit prescription medications are becoming a great concern for us. They have increased worldwide costs and endangered our public safety. Activities related to counterfeit drugs cost our healthcare system an estimated $75 billion in 2010. Many patients were seriously injured and died due to counterfeit medications.…

By: Shannon Tellier – In December 2011, a report written to the United States (U.S.) Surgeon General, Dr. Regina Benjamin, discussed the importance of pharmacists in the healthcare system.  The objective of the report was to obtain support for expanding the roles of pharmacists in patient care, primary care, and public health services.  This evidence-based…

By: Mahdieh Danesh Yazdi – As previously reported, there is currently great concern in the medical community because of the growing number of drug shortages.  Many of these are drugs that are critical to patient care, such as chemotherapy agents and antibiotics.  Last October, President Obama issued an executive order in an attempt to curb…

By: Mohamed Dungersi – On February 28, the U.S. Food and Drug Administration (FDA) approved important safety label changes for the class of cholesterol-lowering drugs known as statins.  Aligned with the FDA’s goal to provide the public with more information for the safe and effective use of statins, the agency made several modifications to the…

By: James Schurr, Pharm.D. Candidate c/o 2014 – Graves’ disease is an autoimmune disorder that results in a state of thyrotoxicosis, or a cause of hyperthyroidism, due to the Immunoglobulin G-mediated agonism of thyroid stimulating hormone (TSH) receptors located on the thyroid.  Stimulation of TSH receptors causes an increase in circulating thyroxine (T4) and triiodothyronine…

By: Ebey P. Soman – Proton pump inhibitors (PPIs) are medications commonly prescribed to treat heartburn, acid reflux disease, and ulcers.  Almost a vast majority of patients in the United States seem to be taking a PPI, either as a prescription or from over-the-counter (OTC).  Researchers recently discovered associations between the long-term use of PPIs…

By: Ronik Saha, Pharm.D. Candidate c/o 2013 – Clopidogrel (Plavix®) is a thienopyridine antiplatelet agent, which exerts its antiplatelet effects via in vivo conversion to an active thiol metabolite that irreversibly blocks the P2Y-12 component of platelet ADP receptors.  This prevents activation of the GP2B/3A complex, thereby preventing platelet aggregation.  Along with aspirin, clopidogrel reduces…

By: Neal Shah – Osteoporosis is a disease of the bone characterized by decreased bone mineral density (BMD), which reduces the ability of bone to provide adequate structural support.  The main cause of this decreased BMD is inadequate calcium intake or absorption.  The decreased BMD can cause diffuse lesions throughout the skeletal system and can…

By: Marie Huang – Each month, Rho Chi Post has the wonderful opportunity to sit down with an inspiring leader among the student pharmacists here at St. John’s University College of Pharmacy and Allied Health Professions – someone who is not afraid to stand apart from the crowd and can be the change he or…

By: Aleena Chacko, Long Island University Pharm.D. Candidate c/o 2013 – Established in 1996, Novartis International AG is a multinational pharmaceutical company based in Switzerland.  On January 8, 2012, Novartis issued a recall on some popular over the counter (OTC) medications in the United States (U.S.) over concerns about broken or incorrect tablets ending up…

By: Alisha Kumar, PharmD Candidate c/o 2012 – Express Scripts proposed a $29 billion acquisition of Medco Health back in July 2011, and Medco’s shareholders almost unanimously accepted the offer.  According to Medco’s press release, the plan was approved by a margin of 99% to 1%, with approximately 72% of its shareholders voting. The two…

By: Ebey P. Soman – Since its discovery in Tanganyika (modern day Mozambique and Tanzania in Africa) in 1952, Chikungunya virus outbreaks have been documented in Africa, South Asia, and Southeast Asia.  Due to recent globalization and increased travel, infection has also spread outside of tropical regions and even into western nations (such as the…

By: Neal Shah – Anticlotting agents are staples in the prevention and treatment of thrombotic disorders, such as deep vein thrombosis, stroke, pulmonary embolism, myocardial infarction, and atrial fibrillation.1  Intravenous medications, such as unfractionated heparin (UFH), low molecular weight heparin (LMWH), and direct thrombin inhibitors (DTI), are commonly used in, both, inpatient and outpatient settings.…

By: Ebey P. Soman – With clearly established roles for pharmacists, compounding is recognized and upheld as a core foundation of the pharmacy profession.   It allows pharmacists to provide unique and tailored medication regimens for their patients.  The U.S. Food and Drug Administration (FDA) thought otherwise when the agency sued Franck’s Lab, Inc., a Florida-based…

By Jena Marion, Pharm.D. Candidate c/o 2013 – On December 12, 2011, the Administrator of the Drug Enforcement Agency (DEA) ruled to place carisoprodol (Soma®) into Schedule IV of the Controlled Substances Act (CSA).  Carisoprodol has been in use since it was approved for marketing in the U.S. in 1959 with the indication of “relief…

By: Mahdieh Danesh Yazdi – We have all heard the mortifying tales of recent attacks on pharmacies by addicts looking to steal prescription pain-killers. Most notable perhaps, was the case of David Laffers. Mr. Laffers walked into Haven Drugs in Medford, NY and killed the pharmacist, a store clerk, and two customers, who happened to…

By: Ruby Lin, Pharm.D. Candidate c/o 2013 – Rotation selection begins around mid-October for fifth year pharmacy students.  You may begin to panic about what sites you should choose from the huge selection that St. John’s University offers.  Your upperclassmen may try to help you by sharing their rotation experiences.  Alas, what do you do…

By: Marie Huang – Each month, Rho Chi Post has the wonderful opportunity to sit down with an inspiring leader among the student pharmacists here at St. John’s University – someone who is not afraid to stand apart from the crowd and can be the change he or she wants to see in the world.…

By: Neal Shah – There are two major classifications of drug-receptor activity: agonism and antagonism. Agonism occurs when a molecule binds to a receptor, causes an exertion of normal receptor operation, and eventually causes a response. Antagonism of a receptor occurs when a molecule binds to the receptor and does not allow activity to occur.1…

By: Ebey P. Soman – Dear Sir or Madam, Christmas is just a few days away, and an amazing year of great challenges, pleasant surprises, and endeavors is coming to a close. From working on Drugs & Diseases courses to simply having the privilege of being part of the profession at the White Coat Ceremony,…

By: Neal Shah – Part I:              Preface. Part II:             Brief review of cardiac electrophysiology. Part III:           Ivabradine as a novel If blocker for the use of stable angina. Part IV:           On the horizon: trimetazidine. – PREFACE When viewed anatomically, the heart may seem like a simple organ.  However, the electrophysiological aspects of the heart are…

By: Jimmy Johnson, PharmD Candidate c/o 2012 – Drug shortages have become more and more of an issue in the health care industry. There are over 200 drugs on the Food and Drug Administration’s (FDA) drug shortage list – a number that has tripled in the last five years.1 The largest impact has been on anesthesia…

By: Mahdieh Danesh Yazdi – Dr. Elizabeth Palillo graduated from the University of Connecticut in 2006. She then worked as a manager at CVS for a year and a half, and eventually moved to New York, where she worked at two other CVS stores. Dr. Palillo then left CVS and joined Bronx-Lebanon Hospital as a…