FDA Approval of Pemazyre® as a First-in-Class Treatment forMyeloid / Lymphoid Neoplasms with FGFR1 Rearrangement
By: Jennifer Galvet, PharmD Candidate c/o 2024 Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases expressed on the cell surface of both developmental and adult cells. Aberrant expression of FGFRs has been implicated in a wide variety of cancers and is considered an oncogenic signaling pathway.1 FGFRs are activated by…